Sacubitril Hemicalcium

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沙库比曲半钙盐 Sacubitril Hemicalcium 1369773-39-6 Cikin Gida
沙库比曲钠盐 149690-05-1 Cikin Gida
LCZ-4 1426129-50-1 Cikin Gida
LCZ-7 1012341-48-8 Cikin Gida
LCZ-8 1012341-50-2 Cikin Gida
LCZ-9 149690-12-0 Cikin Gida

 

Fage

AHU-377 gishiri hemicalcium shine nau'in gishirin hemicalcium na AHU-377.Yana da mai hana neprilysin tare da ƙimar IC50 na 5 nM [1].

AHU-377 da angiotensin II AT1 antagonist valsartan sun tsara LCZ696 a cikin rabon molar 1:1.LCZ696 shine mai hanawa neprilysin mai karɓa na angiotensin.Yana iya rage hawan jini kuma yana iya zama sabon magani don maganin ciwon zuciya.AHU-377 pro-magunguna ne, ana iya jujjuya shi ta hanyar ɓarnawar enzymatic na ethyl ester zuwa nau'i mai aiki LBQ657.An ba da rahoton cewa AHU-377 (30 da 100 mg / kg, PO) na iya haifar da sakamako na antihypertensive a cikin nau'i mai dogara da kashi a cikin ratsan DAHI-SS.Amma a cikin DOCA-gishiri masu hawan jini, yana nuna raguwa mai rauni [2, 3].

Magana:
[1] Ksander GM, Ghai RD, deJesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A. Dicarboxylic acid dipeptide neutral endopeptidase inhibitors.J Med Chem.1995 Mayu 12;38 (10): 1689-700.
[2] Voors AA, Dorhout B, van der Meer P. Matsayi mai yuwuwar valsartan + AHU377 (LCZ696) a cikin maganin cututtukan zuciya.Ra'ayin Kwararru Na Binciken Magunguna.2013 Agusta; 22 (8): 1041-7.
[3] Laxminarayan G Hegde, Cecile Yu, Cheruvu Madhavi et al.Ingancin kwatancen AHU-377, mai hanawa neprilysin mai ƙarfi, a cikin nau'ikan bera guda biyu na hawan jini mai dogaro da ƙara.BMC Pharmacology 2011, 11 (Kashi 1):P33.

Tsarin sinadaran

Sacubitril Hemicalcium

CERTIFICATION

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

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