Sacubitril Hemicalcium

Short Bayani:

Sunan API Nuni Musammantawa US DMF  EU DMF  CEP
Sacubitril Hemicalcium   Cikin-Gida      

Bayanin Samfura

Alamar samfur

CIKAKKEN BAYANI

    库 比 曲 半 钙盐 Sacubitril Hemicalcium 1369773-39-6 Cikin-Gida
    库 比 曲 钠盐 149690-05-1 Cikin-Gida
    LCZ-4 1426129-50-1 Cikin-Gida
    LCZ-7 1012341-48-8 Cikin-Gida
    LCZ-8 1012341-50-2 Cikin-Gida
    LCZ-9 149690-12-0 Cikin-Gida

 

Bayan Fage

AHU-377 gishirin sinadarai shine nau'in gishiri mai sinadarin AHU-377. Yana da mai hana neprilysin tare da ƙimar IC50 na 5 nM [1].

AHU-377 da angiotensin II AT1 antagonist valsartan sun tsara LCZ696 a cikin rabo na 1: 1. LCZ696 mai hanawa neprilysin mai karɓar angiotensin. Zai iya rage hawan jini kuma yana iya zama sabon magani don maganin raunin zuciya. AHU-377 magani ne mai ba da magani, ana iya jujjuya shi ta hanyar tsarkewar ethyl ester a cikin sifa mai aiki ta LBQ657. An bayar da rahoton cewa AHU-377 (30 da 100 mg / kg, PO) na iya haifar da tasirin antihypertensive a cikin yanayin dogaro da kashi a cikin berayen DAHI-SS. Amma a cikin berayen hawan jini na DOCA-gishiri, yana nuna raunin rauni [2, 3].

Nassoshi:
[1] Ksander GM, Ghai RD, deJesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A. Dicarboxylic acid dipeptide tsaka-tsakin endopeptidase masu hanawa. J Med Chem. 1995 Mayu 12; 38 (10): 1689-700.
[2] Voors AA, Dorhout B, van der Meer P. Matsayi mai tasiri na valsartan + AHU377 (LCZ696) a cikin maganin rashin cin nasara zuciya. Kwararren Opin Investig Drugs. 2013 Aug; 22 (8): 1041-7.
[3] Laxminarayan G Hegde, Cecile Yu, Cheruvu Madhavi et al. Amfani da kwatancen AHU-377, mai hana neprilysin mai hanawa, a cikin ƙirar bera biyu na hauhawar jini mai ƙarfi. BMC Pharmacology 2011, 11 (Gudanar da 1): P33.

Tsarin sunadarai

Sacubitril Hemicalcium

TABBATARWA

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

KYAUTA MANAGEMENT

Quality management1

Shawara 18 Ayyuka masu kimanta daidaito waɗanda suka yarda 4, da 6 ayyukan suna ƙarƙashin amincewa.

Quality management2

Tsarin ingantaccen tsarin sarrafa kasa da kasa ya aza tushe mai tushe ga tallace-tallace.

Quality management3

Kulawa mai inganci yana gudana cikin rayuwar rayuwar samfurin gabaɗaya don tabbatar da inganci da tasirin warkewa. 

Quality management4

Ungiyar Rewararrun guwararrun Affairsa'idoji ta goyi bayan buƙatun inganci yayin aikace-aikace da rajista.

GUDANAR DA SANA'A

cpf5
cpf6

Layin Koriya Kwallan Kwalba na Kwalba

cpf7
cpf8

Taiwan CVC Layin Kwallan kwalba

cpf9
cpf10

Layin Lantarki na Hukumar CAM na Italiya

cpf11

Jamusanci Fette Compacting Machine

cpf12

Japan Viswill Tablet Gano

cpf14-1

DCS Gidan Kulawa

ABOKI

Hadin kan duniya
International cooperation
Hadin cikin gida
Domestic cooperation

  • Na Baya:
  • Na gaba:

  • Rubuta sakon ka anan ka turo mana