Bictegravir 1611493-60-7

Takaitaccen Bayani:

Sunan API Nuni Mai ƙirƙira Ranar Karewa Haƙƙin mallaka (Amurka)
Bictegravir 1611493-60-7 Cutar HIV-1 Kimiyyar Gileyad 19 ga Disamba, 2033


Cikakken Bayani

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BAYANIN KYAUTA

Bayani

Bictegravir labari ne, mai ƙarfi mai hanawa HIV-1 haɗawa tare da IC50 na 7.5 nM.

A cikin Vitro

Bictegravir (BIC) yana hana ayyukan canja wuri tare da IC50 na 7.5± 0.3 nM.Dangane da hana shi na ayyukan canja wuri, Bictegravir shine mafi rauni mai hanawa na 3."-ayyukan sarrafa HIV-1 IN, tare da IC50 na 241±51 nm.Bictegravir yana haɓaka tarin 2-LTR da'irori ~ 5-nnki dangane da kulawar izgili kuma yana rage adadin ingantattun samfuran haɗin kai a cikin sel masu kamuwa da ninki 100.Bictegravir yana hana kwafin HIV-1 a cikin duka MT-2 da MT-4 tare da EC50s na 1.5 da 2.4 nM, bi da bi.Bictegravir yana nuna tasirin antiviral mai ƙarfi a cikin CD4+ T lymphocytes na farko da macrophages da aka samu monocyte, tare da EC50s na 1.5±0.3 nM da 6.6±4.1 nM, bi da bi, waɗanda suke daidai da ƙimar da aka samu a cikin layin T-cell[1].

MCE ba ta tabbatar da daidaiton waɗannan hanyoyin da kanta ba.Suna don tunani kawai.

Lambar NCT Mai tallafawa Yanayi Ranar farawa

Mataki

Saukewa: NCT03998176 Jami'ar Nebraska | Kimiyyar Gilead HIV-1-kamuwa da cuta Oktoba 9, 2019

Mataki na 4

Saukewa: NCT03789968 Jami'ar Thomas Jefferson | Jami'ar Maryland, Kwalejin Kwalejin | Lafiyar Jami'ar Indiana | Cibiyar Asibitin Brooklyn | Jami'ar Illinois a Chicago | Jami'ar Kudu maso Gabashin Nova | Jami'ar California, San Francisco HIV+AIDS 1 ga Satumba, 2019
Saukewa: NCT04249037 Jami'ar Colorado, Denver | Kimiyyar Gilead HIV+AIDS Maris 1, 2020

Ba a Aiwatar da shi ba

Saukewa: NCT04132674 Cibiyar Cututtuka masu Yaduwa ta Vancouver Cutar Kwayar cuta ta Human Immunodeficiency I Kamuwa | Amfani da Magunguna Nuwamba 26, 2018

Mataki na 4

Saukewa: NCT04054089 Cristina Mussini | Jami'ar Modena da Reggio Emilia Cutar HIV Satumba 2019

Mataki na 4

Saukewa: NCT0415555 Azienda Ospedaliera Universitaria Senese|Jami'ar Katolika na Tsarkakakkiyar Zuciya|Ospedale Policlinico San Martino|Azienda Ospedaliera San Paolo|Ospedale Amedeo di Savoia HIV-1-kamuwa da cuta Janairu 29, 2020

Mataki na 3

Saukewa: NCT02275065 Kimiyyar Gileyad Cutar HIV-1 Oktoba 2014

Mataki na 1

Saukewa: NCT03711253 Jami'ar Kudancin California Kamuwa da Cutar Kanjamau Oktoba 14, 2019

Mataki na 4

Saukewa: NCT02400307 Kimiyyar Gileyad HIV Afrilu 17, 2015

Mataki na 1

Saukewa: NCT03499483 Lafiyar Al'umma ta Fenway Rigakafin HIV Janairu 24, 2019

Mataki na 4

Saukewa: NCT03502005 Rukunin Bincike na Midland, Inc. | Kimiyyar Gilead Cutar Kwayar Cutar Kariya Maris 1, 2018

Mataki na 4

Tsarin sinadaran

Bictegravir-1611493-60-7

CERTIFICATION

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

INGANTACCEN KYAUTA

Quality management1

Shawara18Ayyukan Ƙididdigar Ƙirar Ƙirar da aka amince da su4, kuma6ayyukan suna ƙarƙashin amincewa.

Quality management2

Babban tsarin kula da ingancin ingancin ƙasa ya kafa tushe mai ƙarfi don siyarwa.

Quality management3

Ingantacciyar kulawa tana gudanar da duk tsawon rayuwar samfurin don tabbatar da inganci da tasirin warkewa.

Quality management4

Mawakan da ake gudanarwa na kwararru yana tallafawa ingancin bukatun yayin aikace-aikacen da rajista.

SAMUN SARAUTA

cpf5
cpf6

Layin Packaging Bottled na Koriya Countec

cpf7
cpf8

Layin Marufi na CVC Taiwan

cpf9
cpf10

Layin Marufi na Hukumar CAM Italiya

cpf11

Jamus Fette Compacting Machine

cpf12

Japan Viswill Tablet Detector

cpf14-1

Dakin Kulawa na DCS

ABUNCI

Hadin gwiwar kasa da kasa
International cooperation
Hadin kai na cikin gida
Domestic cooperation

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