Fage

AHU-377 gishiri hemicalcium shine nau'in gishirin hemicalcium na AHU-377. Yana da mai hana neprilysin tare da ƙimar IC50 na 5 nM [1].

AHU-377 da angiotensin II AT1 antagonist valsartan sun tsara LCZ696 a cikin rabon molar 1:1. LCZ696 shine mai hanawa neprilysin mai karɓa na angiotensin. Yana iya rage hawan jini kuma yana iya zama sabon magani don maganin ciwon zuciya. AHU-377 pro-magani ne, ana iya canza shi ta hanyar ɓarnawar enzymatic na ethyl ester zuwa nau'i mai aiki LBQ657. An bayar da rahoton cewa AHU-377 (30 da 100 mg / kg, PO) na iya haifar da sakamako na antihypertensive a cikin nau'i mai dogara da kashi a cikin ratsan DAHI-SS. Amma a cikin berayen hawan jini na DOCA-gishiri, yana nuna raguwa mai rauni [2, 3].

Magana:
[1] Ksander GM, Ghai RD, deJesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A. Dicarboxylic acid dipeptide neutral endopeptidase inhibitors. J Med Chem. 1995 Mayu 12; 38 (10): 1689-700.
[2] Voors AA, Dorhout B, van der Meer P. Matsayi mai yuwuwar valsartan + AHU377 (LCZ696) a cikin maganin cututtukan zuciya. Ra'ayin Kwararru Na Binciken Magunguna. 2013 Agusta; 22 (8): 1041-7.
[3] Laxminarayan G Hegde, Cecile Yu, Cheruvu Madhavi et al. Ingancin kwatancen AHU-377, mai hanawa neprilysin mai ƙarfi, a cikin nau'ikan bera guda biyu na hawan jini mai dogaro da ƙara. BMC Pharmacology 2011, 11 (Kashi 1):P33.

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