Pregabalin

Short Bayani:

Sunan API Nuni Musammantawa US DMF  EU DMF  CEP
Pregabalin Farfadiya / Neuralgia Cikin-Gida / EP 22223 CEP2016-141

Bayanin Samfura

Alamar samfur

CIKAKKEN BAYANI

Pregabalin ba GABAA bane ko GABAB agonist agonist.
Pregabalin shine gabapentinoid kuma yana aiki ta hana wasu tashoshin alli. Musamman layin haɗin yanar gizo ne na site2δ mai taimako na wasu tashoshin alli masu ƙarfi (VDCCs), kuma hakan yana aiki a matsayin mai hana α2δ mai ɗauke da VDCCs. Akwai ƙananan two2δ masu ɗaurin magani, α2δ-1 da α2δ-2, kuma pregabalin yana nuna irin wannan alaƙar don (kuma saboda rashin zaɓi tsakanin) waɗannan rukunin yanar gizon biyu. Pregabalin zaɓaɓɓe ne a cikin ɗaure shi zuwa α2δ VDCC subunit. Duk da cewa pregabalin analo ne na GABA, ba ya rataya ga masu karɓar GABA, baya canzawa zuwa GABA ko wani agonist mai karɓar GABA a cikin rayuwa, kuma baya yin canjin yanayin GABA kai tsaye ko canzawa. Koyaya, pregabalin an samo shi don samar da haɓakar dogaro a cikin ƙwaƙwalwar ƙwaƙwalwar ƙwayar L-glutamic acid decarboxylase (GAD), enzyme da ke da alhakin hada GABA, don haka yana iya samun wasu tasirin GABAergic kai tsaye ta hanyar ƙara matakan GABA a cikin kwakwalwa. A halin yanzu babu wata shaida da ke nuna cewa tasirin pregabalin yana yin sulhu ta kowace hanya in ban da hana D2a dauke da VDCCs. Dangane da haka, hana α2δ-1 dauke da VDCC ta pregabalin ya zama yana da alhakin abubuwan da ke haifar da tashin hankali, analgesic, da tashin hankali.
Α-amino acid masu ƙarancin gaske L-leucine da L-isoleucine, waɗanda suke kamanceceniya da pregabalin da sauran gabapentinoids a cikin tsarin sunadarai, haɗuwa ce ta α2δ VDCC da ke da kamanceceniya kamar gabapentinoids (misali, IC50 = 71 nM na L- isoleucine), kuma suna nan cikin ruwan kwayar halittar ɗan adam a ƙananan micromolar (misali, 12.9 μM na L-leucine, 4.8 μM na L-isoleucine). An kaddara cewa zasu iya kasancewa hadaddun jijiyoyin mai karfin halittar kuma su iya gwagwarmaya su haifar da illa ga gabapentinoids. Daidai ne, yayin da gabapentinoids kamar pregabalin da gabapentin suna da kusancin nanomolar don α2δ subunit, ƙarfinsu a vivo yana cikin ƙananan kewayon micromolar, kuma gasa don ɗaurewa ta ƙarancin L-amino acid mai yiwuwa ana da alhakin wannan sabanin.

An sami Pregabalin yana da kusanci sau 6 fiye da gabapentin don α2δ mai dauke da VDCC a cikin binciken daya. Koyaya, wani binciken ya gano cewa pregabalin da gabapentin suna da irin wannan alaƙa ga ɗan adam mai sake haɗawa sub2δ-1 (Ki = 32 nM da 40 nM, bi da bi). A kowane hali, pregabalin ya fi ƙarfin gabapentin sau 2 zuwa 4 fiye da yadda ake yin amfani da maganin, kuma, a cikin dabbobi, ya nunka ya ninka sau 3 zuwa 10 fiye da gabapentin a matsayin mai hana ɗaukar ciki.

TABBATARWA

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

KYAUTA MANAGEMENT

Quality management1

Shawara 18 Ayyuka masu kimanta daidaito waɗanda suka yarda 4, da 6 ayyukan suna ƙarƙashin amincewa.

Quality management2

Tsarin ingantaccen tsarin sarrafa kasa da kasa ya aza tushe mai tushe ga tallace-tallace.

Quality management3

Kulawa mai inganci yana gudana cikin rayuwar rayuwar samfurin gabaɗaya don tabbatar da inganci da tasirin warkewa. 

Quality management4

Ungiyar Rewararrun guwararrun Affairsa'idoji ta goyi bayan buƙatun inganci yayin aikace-aikace da rajista.

GUDANAR DA SANA'A

cpf5
cpf6

Layin Koriya Kwallan Kwalba na Kwalba

cpf7
cpf8

Taiwan CVC Layin Kwallan kwalba

cpf9
cpf10

Layin Lantarki na Hukumar CAM na Italiya

cpf11

Jamusanci Fette Compacting Machine

cpf12

Japan Viswill Tablet Gano

cpf14-1

DCS Gidan Kulawa

ABOKI

Hadin kan duniya
International cooperation
Hadin cikin gida
Domestic cooperation

  • Na Baya:
  • Na gaba:

  • Rubuta sakon ka anan ka turo mana

    Kayan samfuran