Daclatasvir Dihydrochloride
Bayani
Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) abu ne mai ƙarfi kuma mai aiki da baki.HCV NS5A sunadaranmai hanawa tare daEC50s kewayon 9-146 pM donmahara HCV replicon genotypes.Daclatasvir dihydrochloride kuma aOrganic anion jigilar polypeptide 1B (OATP1B)kumaSaukewa: OATP1B3mai hanawa tare daIC50s na 1.5 µM da 3.27 µM, bi da bi.
IC50& Target
EC50: 50 pM (HCV replicon genotype 1a), 9 pM (HCV replicon genotype 1b), 71 pM (HCV replicon genotype 2a), 146 pM (HCV replicon genotype 3a), 12 pM (HCV replicon genotype 4a) da kuma 3 pM. HCV replicon genotype 5a)[1]
Kd: 8 nM (NS5A33-202) da 210 nM (NS5A26-202)[2]
IC50: 1.5 µM (OATP1B) da 3.27 µM (OATP1B3)[3]
A cikin Vitro
Daclatasvir (BMS-790052) yana nuna ayyukan hanawa mai ƙarfi ga duk nau'ikan genotypes da aka gwada, tare da EC50dabi'u daga 9 pM zuwa 146 pM.Daclatasvir yana hana HCV replicon genotype 1a, 1b, 2a, 3a, 4a da 5a tare da EC50ƙimar 50 pM, 9 pM, 71 pM, 146 pM, 12 pM da 33 pM, bi da bi.Daclatasvir shine mai hanawa mai ƙarfi na JFH-1 genotype 2a mai kamuwa da cuta wanda ke kwaikwaya a cikin al'adun tantanin halitta (EC).50= 28pm)[1].Daclatasvir (BMS-790052) yana ɗaure tam zuwa NS5A33-202 da NS5A26-202 tare da Kds na 8 nM da 210 nM, bi da bi[2].
Ajiya
| Foda | -20°C | shekaru 3 |
| 4°C | shekaru 2 | |
| A cikin ƙarfi | -80°C | Wata 6 |
| -20°C | Wata 1 |
Gwajin asibiti
| Lambar NCT | Mai tallafawa | Yanayi | Ranar farawa | Mataki |
| Saukewa: NCT03369327 | Jami'ar Tehran ta Kimiyyar Kiwon Lafiya | Kamfanin Magunguna na Rojan Pharma | Kamuwa da Cutar Hepatitis C, Raddi ga Therapy na | Kwayar cuta ta Immunodeficiency na ɗan adam | 1 ga Janairu, 2017 | Mataki na 3 |
| Saukewa: NCT03485846 | R-Pharm|Almedis | Hepatitis C na kullum Genotype 1b | Nuwamba 27, 2017 | Mataki na 2 |
| Saukewa: NCT01016912 | Bristol-Myers Squibb | Cutar Hanta | Disamba 2009 | Mataki na 2 |
| Saukewa: NCT01629732 | Bristol-Myers Squibb | Cutar Hepatitis C | Maris 2013 | Mataki na 2 |
| Saukewa: NCT01497834 | Bristol-Myers Squibb | Hepatitis C | Janairu 2012 | Mataki na 3 |
| NCT01973049 | Bristol-Myers Squibb | Hepatitis C | Disamba 2013 | Mataki na 3 |
| Saukewa: NCT00663208 | Bristol-Myers Squibb | Hepatitis C na kullum | Mayu 2008 | Mataki na 2 |
| NCT02576314 | Cibiyar Binciken Bil Adama da Lafiya | Asibitin Beijing 302 | Kamuwa da Cutar Hepatitis C na yau da kullun | Mayu 2015 | Mataki na 3 |
| Saukewa: NCT02756936 | Cibiyar Bincike ta Gaskiya, Masar | Masana'antun Magunguna na Zeta Pharma | Lafiyayyan | Fabrairu 2016 | Mataki na 1 |
| Saukewa: NCT02771405 | Cibiyar Nazarin Ciwon Hanta ta Ƙasa & Cibiyar Nazarin Magungunan Wuta | Jami'ar Alkahira | Hepatitis C, Chronic | Ciwon Hanta | Maris 2016 | Mataki na 3 |
| Saukewa: NCT03706898 | Viriom | HIV-1-kamuwa da cuta|Lalacewar Hanta | Oktoba 1, 2018 | Mataki na 1 |
| Saukewa: NCT02319031 | Bristol-Myers Squibb | Hepatitis C | Fabrairu 2015 | Mataki na 3 |
| Saukewa: NCT02124044 | Cibiyar Kula da Lafiya ta Kasa (CC) | Cibiyar Nazarin Allergy da Cututtuka (NIAID) | Bristol-Myers Squibb | HIV-HCV | Fabrairu 2014 | Mataki na 2 |
| Saukewa: NCT02551861 | Bristol-Myers Squibb | Hepatitis C | Disamba 2015 | Mataki na 2 |
| Saukewa: NCT00859053 | Bristol-Myers Squibb | Ciwon Hanta | Maris 2009 | Mataki na 1 |
| Saukewa: NCT01257204 | Bristol-Myers Squibb | Cutar Hepatitis C | Disamba 2010 | Mataki na 2 |
| Saukewa: NCT03063879 | Tehran University of Medical Sciences|Ahvaz Jundishapur University of Medical Sciences|Shiraz University of Medical Sciences|Jami'ar Hamadan | Hepatitis C, Na Yaudare|Rashin Ciwon Renal | Afrilu 1, 2017 | Mataki na 4 |
| Saukewa: NCT01017575 | Bristol-Myers Squibb | Cutar Hanta | Disamba 2009 | Mataki na 2 |
| Saukewa: NCT02865369 | Sang Gyune Kim | Jami'ar Seoul National University Boramae | Asibitin Severance | Asibitin Jami'ar Inha | Jami'ar Koriya | Jami'ar Gachon Gil Medical Center | Asibitin Jami'ar Hanyang | Hepatitis C na kullum | Satumba 2016 |
|
| Saukewa: NCT04070235 | Nanjing Sanhome Pharmaceutical Co., Ltd. | Hepatitis C, na kullum | Maris 29, 2019 | Darasi na 2|File Na 3 |
| Saukewa: NCT03487848 | Bristol-Myers Squibb | Hepatitis C | Ciwon Hanta | Mayu 18, 2018 | Mataki na 2 |
| Saukewa: NCT00904059 | Bristol-Myers Squibb | Hepatitis C | Mayu 2009 | Mataki na 1 |
| Saukewa: NCT02107365 | Cibiyar Nazarin Kiwon Lafiya da Kiwon Lafiya ta Faransa-Hukumar Bincike ta Ƙasa ta Faransa akan AIDS da Ciwon Hanta (Inserm-ANRS)|Bristol-Myers Squibb | Hepatitis C Virus Genotype 4 Kamuwa da cuta | Nuwamba 2013 | Mataki na 2 |
| Saukewa: NCT02397395 | Janssen R&D Ireland | Raunin Renal |Cutar cutar Renal | Mayu 2015 | Mataki na 2 |
| Saukewa: NCT03169348 | Jami'ar Assiut | Hepatitis C | Nuwamba 1, 2017 | Ba a Aiwatar da shi ba |
| Saukewa: NCT02323594 | Bristol-Myers Squibb | Cutar Hanta | Disamba 2014 | Mataki na 1 |
| Saukewa: NCT03537196 | Cibiyar Nazarin Kiwon Lafiya da Kiwon Lafiya ta Faransa-Hukumar Bincike ta Ƙasa ta Faransa akan AIDS da Hepatitis Viral (Inserm-ANRS) | Hepatitis C | Amfani da Magunguna | Cutar Hepatitis C | Nuwamba 13, 2018 | Mataki na 4 |
| Saukewa: NCT02103569 | Bristol-Myers Squibb | Hepatitis C | Afrilu 2014 | Mataki na 1 |
| Saukewa: NCT02772744 | Jami'ar Zagazig | Jami'ar Cairo | Hepatitis C | Nuwamba 1, 2017 |
|
| Saukewa: NCT01718158 | Bristol-Myers Squibb | Hepatitis C | Janairu 2013 | Mataki na 3 |
| Saukewa: NCT02496078 | Bristol-Myers Squibb | Hepatitis C | Agusta 2015 | Mataki na 3 |
| Saukewa: NCT01425970 | Bristol-Myers Squibb | Hepatitis C | Mayu 2012 | Mataki na 2 |
| Saukewa: NCT01471574 | Bristol-Myers Squibb | Hepatitis C, Genotype 1 | Disamba 2011 | Mataki na 3 |
| Saukewa: NCT01573351 | Bristol-Myers Squibb | Cutar Hepatitis C | Mayu 2012 | Mataki na 3 |
| NCT01938625 | Janssen R&D Ireland | Hepatitis C, na kullum | Disamba 12, 2013 | Mataki na 2 |
| Saukewa: NCT01492426 | Bristol-Myers Squibb | Hepatitis C | Janairu 2012 | Mataki na 3 |
| Saukewa: NCT03480932 | Johns Hopkins Bloomberg Makarantar Kiwon Lafiyar Jama'a | Cibiyar Nazarin Magunguna ta Kasa (NIDA) | Hepatitis C, na kullum | Fabrairu 2, 2018 | Darasi na 2|File Na 3 |
| Saukewa: NCT03163849 | Jami'ar Assiut | Hepatitis na kullum c | 1 ga Satumba, 2019 | Mataki na 3 |
| Saukewa: NCT01581203 | Bristol-Myers Squibb | Cutar Hepatitis C | Mayu 2012 | Mataki na 3 |
| Saukewa: NCT01492504 | Bristol-Myers Squibb | Hepatitis C | Fabrairu 7, 2012 |
|
| Saukewa: NCT03686722 | Mohamed Raslan | Jami'ar Ain Shams | Cibiyar Nazarin Magunguna, Alkahira, Masar | Ciwon sukari Mellitus, Nau'in 2|Hepatitis C|Mu'amalar Magunguna | Satumba 9, 2017 | Mataki na 1 |
| Saukewa: NCT02262728 | Janssen Research & Development, LLC | Hepatitis C, na kullum | Satumba 30, 2014 | Mataki na 2 |
| Saukewa: NCT02349048 | Janssen Research & Development, LLC | Cutar Hepatitis C | Janairu 2015 | Mataki na 2 |
| Saukewa: NCT03882307 | Jami'ar Assiut | Hepatitis C, na kullum | Mayu 2020 | Farkon Mataki na 1 |
| Saukewa: NCT02758509 | Parc de Salut Mar | Hepatitis C | Ciwon Ciki | Janairu 1, 2010 |
|
| Saukewa: NCT0179591 | Bristol-Myers Squibb | Hepatitis C | Maris 2013 | Mataki na 2 |
| Saukewa: NCT03549832 | Jami'ar Assiut | Jami'ar Sohag | Jami'ar Kudancin Valley | HCV Coinfection | 1 ga Janairu, 2018 | Ba a Aiwatar da shi ba |
| NCT02161939 | Bristol-Myers Squibb | Hepatitis C na kullum |
| |
| Saukewa: NCT01309932 | Bristol-Myers Squibb | Hepatitis C | Maris 2011 | Mataki na 2 |
| NCT01995266 | Bristol-Myers Squibb | Hepatitis C | Fabrairu 28, 2014 | Mataki na 3 |
| Saukewa: NCT02640157 | AbbVie | Hepatitis C | Ciwon Hepatitis C | Cutar Hanta ta Genotype 3 | Disamba 2015 | Mataki na 3 |
| Saukewa: NCT02032875 | Bristol-Myers Squibb | Hepatitis C | Maris 2014 | Mataki na 3 |
| Saukewa: NCT02624063 | Jami'ar Tarayya ta Sao Paulo | Hepatitis C, na kullum | Disamba 2015 | Mataki na 4 |
| Saukewa: NCT00546715 | Bristol-Myers Squibb | Hepatitis C na kullum | Nuwamba 2007 | Darasi Na 1 | Darasi Na 2 |
| Saukewa: NCT01718145 | Bristol-Myers Squibb | Kamuwa da Cutar Hepatitis C | Nuwamba 2012 | Mataki na 3 |
| Saukewa: NCT01616524 | Bristol-Myers Squibb | Hepatitis C Virus (HCV) | Yuli 2012 | Mataki na 3 |
| Saukewa: NCT02032901 | Bristol-Myers Squibb | Hepatitis C | Janairu 2014 | Mataki na 3 |
| Saukewa: NCT03540212 | Ain Shams University | Cutar cututtuka na HCV na kullum | Disamba 10, 2017 | Darasi na 2|File Na 3 |
| Saukewa: NCT02097966 | Bristol-Myers Squibb | Hepatitis C na kullum |
| |
| Saukewa: NCT02596880 | Tehran University of Medical Sciences | Hepatitis C|Cirrhosis | Satumba 2015 | Mataki na 3 |
| NCT04019717 | Abubuwan da aka bayar na Atea Pharmaceuticals, Inc. | Hepatitis C|Hepatitis C, Na Da'a | Yuni 20, 2019 | Mataki na 2 |
| Saukewa: NCT02992457 | Jami'ar Tanta | Hepatitis C | Janairu 2015 | Mataki na 4 |
| Saukewa: NCT03547895 | Jami'ar Zagazig | Decompensated Cirrhosis | Yuni 1, 2015 | Ba a Aiwatar da shi ba |
| Saukewa: NCT03004625 | Asibitin tunawa da Jami'ar Kiwon Lafiya ta Kaohsiung Chung-Ho | Asibitin tunawa da Chang Gung | Asibitin Jami'ar Taiwan na kasa | Hepatitis C | Nuwamba 2016 | Mataki na 3 |
| Saukewa: NCT01051414 | Bristol-Myers Squibb | Cutar Hanta | Afrilu 2010 | Mataki na 2 |
| Saukewa: NCT02309450 | Cibiyar Nazarin Kiwon Lafiya da Kiwon Lafiya ta Faransa-Hukumar Bincike ta Ƙasa ta Faransa akan AIDS da Ciwon Hanta (Inserm-ANRS)|Bristol-Myers Squibb | Hepatitis C Virus Genotype 4 Kamuwa da cuta | Disamba 2014 | Mataki na 2 |
| Saukewa: NCT01628692 | Bristol-Myers Squibb | Janssen Bincike & Ci gaba, LLC | Cutar Hepatitis C | Yuli 2012 | Mataki na 2 |
| NCT03186313 | Asibitin Hanta na Masar | Asibitin Wadi El Nil | Hepatitis C | Satumba 2016 | Mataki na 3 |
| Saukewa: NCT03063723 | Asibitin Haɗin Kai na Uku, Jami'ar Sun Yat-Sen | Hepatitis C na yau da kullun (Rashin lafiya) | 1 ga Janairu, 2016 |
|
| Saukewa: NCT00983957 | Bristol-Myers Squibb | Hepatitis C na kullum | Oktoba 2009 | Mataki na 1 |
| Saukewa: NCT01725542 | Cibiyar Nazarin Kiwon Lafiya da Kiwon Lafiya ta Faransa-Hukumar Bincike ta Ƙasa ta Faransa akan AIDS da Ciwon Hanta (Inserm-ANRS)|Bristol-Myers Squibb | HCV-HIV Co-kamuwa | Disamba 2012 | Mataki na 2 |
| Saukewa: NCT02282709 | Gidauniyar Binciken Hanta | Hepatitis C na kullum | Fabrairu 2014 | Mataki na 3 |
| Saukewa: NCT02032888 | Bristol-Myers Squibb | Hepatitis C | Fabrairu 2014 | Mataki na 3 |
| Saukewa: NCT03247296 | Jami'ar MTI | Hepatitis C | Fabrairu 28, 2017 |
|
| Saukewa: NCT01389323 | Bristol-Myers Squibb | Hepatitis C | Satumba 2011 | Mataki na 3 |
| Saukewa: NCT02556086 | Bristol-Myers Squibb | Hepatitis C | Disamba 2015 | Mataki na 2 |
| Saukewa: NCT01741545 | Bristol-Myers Squibb | Cutar Hepatitis C | Maris 31, 2013 | Mataki na 3 |
| Saukewa: NCT01866930 | Bristol-Myers Squibb | Kamuwa da Cutar Hepatitis C na yau da kullun | Yuli 11, 2013 | Mataki na 3 |
| Saukewa: NCT02268864 | Janssen-Cilag International N.V. girma | Hepatitis C, na kullum | Janairu 2015 | Mataki na 2 |
| Saukewa: NCT01797848 | Bristol-Myers Squibb | Hepatitis C | Yuni 2014 | Mataki na 3 |
| Saukewa: NCT03166280 | Eman Sayed Hassan Abd Allah|Assiut University | Hepatitis C | Yuni 2017 |
|
| Saukewa: NCT02159352 | Bristol-Myers Squibb | Hepatitis C | Yuni 2014 | Mataki na 1 |
| Saukewa: NCT01125189 | Bristol-Myers Squibb | Cutar Hepatitis C | Yuli 2010 | Mataki na 2 |
| Saukewa: NCT03748745 | Nanjing Sanhome Pharmaceutical Co., Ltd. | Mu'amalar Magunguna | Nuwamba 19, 2018 | Mataki na 1 |
| Saukewa: NCT01012895 | Bristol-Myers Squibb | Hepatitis C na kullum | Disamba 2009 | Mataki na 2 |
| Saukewa: NCT0256588 | Jami'ar Radboud | Hepatitis C | HIV | Nuwamba 2015 | Mataki na 1 |
| Saukewa: NCT0255943 | Cibiyar Binciken Bil Adama da Lafiya | Asibitin Beijing 302 | Asibitin Nanfang na Jami'ar Kiwon Lafiya ta Kudancin | Ciwon Hepatitis C na Yau da kullum|HBV Coinfection|Hepatitis B Reactivation | Fabrairu 2015 | Darasi na 2|File Na 3 |
| Saukewa: NCT02304159 | Tarek I. Hassanein, MD, FACP, FAG, AGAF|Cibiyar Bincike ta Kudancin California | Hepatitis C|Cirrhosis | Janairu 2015 | Mataki na 4 |
| Saukewa: NCT02580474 | Myeong Jun Song|Bristol-Myers Squibb| Asibitin Jami'ar Soonchunhyang | Jami'ar Dankook | Asibitin Jami'ar Chungnam | Asibitin Jami'ar Konyang | Asibitin Jami'ar Eulji | Asibitin Saint Vincent's, Koriya | Asibitin Jami'ar Konkuk , Koriya | Asibitin Severance | Asibitin Guro Jami'ar Koriya | Babban Asibitin Eulji | Jami'ar Katolika ta Koriya | Hepatitis C | Fabrairu 2016 | Mataki na 4 |
| Saukewa: NCT02104843 | Bristol-Myers Squibb | Hepatitis C | Afrilu 2014 | Mataki na 1 |
| Saukewa: NCT01428063 | Bristol-Myers Squibb | Kamuwa da Cutar Hepatitis C | Satumba 2011 | Mataki na 2 |
| Saukewa: NCT02123654 | Bristol-Myers Squibb | Kamuwa da Cutar Hepatitis C | Afrilu 2014 | Mataki na 3 |
| Saukewa: NCT02565862 | Jami'ar Radboud | Hepatitis C | Ciwon sukari Mellitus | Janairu 2016 | Mataki na 1 |
| Saukewa: NCT04211844 | Ain Shams University | Hepatitis C na kullum | Oktoba 1, 2019 |
|
| Saukewa: NCT00874770 | Bristol-Myers Squibb | Cutar Hanta | Yuni 2009 | Mataki na 2 |
| Saukewa: NCT03883698 | Sanjay Gandhi Postgraduate Institute of Medical Sciences | Rashin Ciwon Koda, Tsawon Lokaci | Hepatitis C | Maris 15, 2019 | Mataki na 3 |
| Saukewa: NCT01448044 | Bristol-Myers Squibb | Hepatitis C | Disamba 2011 | Mataki na 3 |
| Saukewa: NCT01359644 | Bristol-Myers Squibb | Pharmasset | Hepatitis C na kullum | Yuni 2011 | Mataki na 2 |
| Saukewa: NCT01842451 | Kudin hannun jari Vertex Pharmaceuticals Incorporated | Hepatitis C | CHC|HCV|Hepatitis C | Yuni 2013 | Mataki na 2 |
| Saukewa: NCT02762448 | Tainan Municipal Hospital | Hepatitis c | Yuli 2016 |
|
| Saukewa: NCT02473211 | Cibiyar Binciken Bil Adama da Lafiya | Asibitin Beijing 302 | Kamuwa da Cutar Hepatitis C na yau da kullun | Janairu 2015 | Darasi na 2|File Na 3 |
| Saukewa: NCT01455090 | Bristol-Myers Squibb | Hepatitis C na kullum | Nuwamba 30, 2011 | Mataki na 2 |
| Saukewa: NCT03490097 | Ain Shams University | Hepatitis na kullum c|Ciwon Jiki | 1 ga Disamba, 2017 | Darasi na 2|File Na 3 |
| Saukewa: NCT01170962 | Bristol-Myers Squibb | Cutar Hepatitis C | Agusta 2010 | Mataki na 2 |
| Saukewa: NCT02333292 | Asibitin Jami'ar Valme | Asibitin del SAS de Jerez | Asibitin Janar Universitario Elche | Asibitin La Línea de la Concepción | Complexo Hospitalario Universitario de A Coruña Asibitin General Universitario de Alicante|Asibitin Universitario Araba|Asibitin Royo Vilanova | Asibitin Universitario de Burgos Navarra | Asibitin Clinico Universitario San Cecilio | Asibitin Universitario La Fe da Luz | Babban Asibiti Universitario de Castellón | Asibitin Parc Taulí, Sabadell | Kamuwa da Cutar Hepatitis C na yau da kullun | Disamba 2014 |
|
| Saukewa: NCT03200184 | Tehran University of Medical Sciences | Hepatitis C | 1 ga Satumba, 2016 | Mataki na 4 |
| Saukewa: NCT03188276 | Asibitin Haɗin Kai na Uku, Jami'ar Sun Yat-Sen | Hepatitis C na kullum | Fabrairu 1, 2016 | Farkon Mataki na 1 |
| Saukewa: NCT01830205 | Bristol-Myers Squibb | Hepatitis C | Satumba 2012 | Mataki na 1 |
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