Fage

Canagliflozin labari ne, mai ƙarfi, kuma mai zaɓin mai hana jigilar sodium glucose co-transporter (SGLT) 2 [1].An tabbatar da cewa Canagliflozin na iya ƙara haɓakar glucose na fitsari ta hanyar rage madaidaicin matakin glucose na koda da kuma raguwar sake shan glucose da aka tace [2].

An nuna Canagliflozin don hana abubuwan da ake amfani da su na 14C-AMG na Na + a cikin CHO-hSGLT2, CHO-rat SGLT2 da CHO-mouse SGLT2 tare da ƙimar IC50 na 4.4, 3.7 da 2.0 nM, bi da bi [1].

An ba da rahoton Canagliflozin don rage matakan glucose na jini (BG) dangane da kashi biyun db/db Mice da Zucker mai ciwon sukari (ZDF) berayen.Bugu da ƙari, canagliflozin ya tabbatar da rage ƙimar musayar numfashi, da nauyin jiki a cikin berayen DIO da berayen ZDF [1].

Ana iya ɗaukar Canagliflozin da baki [1].

Magana:
[1] Liang Y1, Arakawa K, Ueta K, Matsushita Y, Kuriyama C Martin T, Du F, Liu Y, Xu J, Conway B, Conway J, Polidori D, Ways K, Demarest K. Tasirin canagliflozin akan kofa na koda don glucose, glycemia, da nauyin jiki a cikin al'ada da nau'in dabbobi masu ciwon sukari.PLoS Daya.2012; 7 (2): e30555
[2] Sarnoski-Brocavich S, Hilas O. Canagliflozin (Invokana), Wakilin Baka Novel Don Nau'in-2 Ciwon sukari.P T. 2013 Nuwamba; 38 (11): 656-66

Bayanin Samfura

Bahia Abbas Moussa, Marianne Alphonse Mahrouse, et al."Hanyoyin ƙuduri daban-daban don sarrafa abubuwan da suka mamaye: Aikace-aikacen don tantance sabbin magungunan hypoglycemic da aka haɗa a cikin nau'ikan nau'ikan nau'ikan magunguna na haɗin gwiwa."Spectrochimica Acta Sashe na A: Molecular da Biomolecular Spectroscopy Akwai akan layi 20 Yuni 2018.

Tsarin sinadaran