Fage

Agomelatine agonist ne na masu karɓar melatonin kuma mai adawa da mai karɓa na 5-HT2C na serotonin tare da kimar Ki na 0.062nM da 0.268nM da darajar IC50 na 0.27μM, bi da bi na MT1, MT2 da 5-HT2C [1].

Agomelatine wani maganin rage damuwa ne na musamman kuma an ƙirƙira shi don maganin babban rashin damuwa (MDD).Agomelatine zaɓi ne akan 5-HT2C.Yana nuna ƙananan alaƙa ga ɗan adam 5-HT2A da 5-HT1A.Don masu karɓar melatonin, agomelatine yana nuna alaƙa iri ɗaya ga ɗan adam MT1 da MT2 tare da ƙimar Ki na 0.09nM da 0.263nM, bi da bi.A cikin nazarin vivo, agomelatine yana haifar da haɓakar dopamine da matakan noradrenaline ta hanyar toshe shigarwar inhibitory na 5-HT2C.Haka kuma, gudanar da agomelatine yana magance raguwar damuwa da ke haifar da cin sucrose a cikin ƙirar bera na baƙin ciki.Bayan haka, agomelatine yana aiki yana rage tasirin tashin hankali a cikin ƙirar rodent na damuwa [1].

Magana:
[1] Zupancic M, Guilleminault C. Agomelatine.Magungunan CNS, 2006, 20 (12): 981-992.

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