Fage

Agomelatine agonist ne na masu karɓar melatonin kuma mai adawa da mai karɓa na 5-HT2C na serotonin tare da kimar Ki na 0.062nM da 0.268nM da darajar IC50 na 0.27μM, bi da bi na MT1, MT2 da 5-HT2C [1].

Agomelatine wani magani ne na musamman kuma an ƙirƙira shi don maganin babban rashin damuwa (MDD). Agomelatine zaɓi ne akan 5-HT2C. Yana nuna ƙananan alaƙa ga ɗan adam 5-HT2A da 5-HT1A. Don masu karɓar melatonin, agomelatine yana nuna alaƙa iri ɗaya ga ɗan adam MT1 da MT2 tare da ƙimar Ki na 0.09nM da 0.263nM, bi da bi. A cikin nazarin vivo, agomelatine yana haifar da haɓakar dopamine da matakan noradrenaline ta hanyar toshe shigarwar inhibitory na 5-HT2C. Haka kuma, gudanar da agomelatine yana magance raguwar damuwa da ke haifar da cin sucrose a cikin ƙirar bera na baƙin ciki. Bayan haka, agomelatine yana aiki yana rage tasirin tashin hankali a cikin ƙirar rodent na damuwa [1].

Magana:
[1] Zupancic M, Guilleminault C. Agomelatine. Magungunan CNS, 2006, 20 (12): 981-992.

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