Fage

Tofacitinib citrate, wanda aka fi sani da CP-690550 citrate, shine mai hanawa mai karfi na janus kinase 3 (JAK3), wani ƙwayar hematopoetic mai ƙuntataccen tyrosine kinase wanda ke shiga cikin siginar siginar da ke daidaita rayuwar lymphocyte, yaduwa, bambanta, da apoptosis. Hani shine takamaiman JAK3 tare da zaɓin 1000-ninka fiye da sauran kinase na dangin JAK. Bayan hana JAKS (IC50 = 1 nM), tofacitinib citrate kuma yana hana janus kinase 2 (JAK2) da janus kinase 1 (JAK1) tare da 20- da 100-ninka ƙasa da ƙarfi bi da bi. Duk da haka, a cikin binciken da aka yi kwanan nan, haɗin haɗin (Ki) na tofacitinib citrate zuwa JAK1, JAK2, da JAK3 an ruwaito su zama 1.6 nM, 21.7 nM, da 6.5 nM bi da bi.

Magana

Lalitha Vijayakrishnan, R. Venkataramanan da Palak Gulati. Yin maganin kumburi tare da janus kinase inhibitor CP-690,550. Abubuwan da ke faruwa a Kimiyyar Magunguna 2011: 32 (1); 25-34

Bayanin Samfura

• 1. Panagi I, Jennings E, et al. "Salmonella Effector SteE Yana Canza Mammalian Serine/Treonine Kinase GSK3 zuwa Tyrosine Kinase zuwa Jagorar Macrophage Polarization." Cell Host Microbe. 2020;27 (1):41–53.e6. Saukewa: 31862381
• 2. McInnes IB, Byers NL, et al. "Kwantatawa na baricitinib, upadacitinib, da tofacitinib sun daidaita tsarin siginar cytokine a cikin ƙananan ƙwayoyin leukocyte na ɗan adam." Arthritis Res Ther. 2 ga Agusta 2019 (1): 183. Saukewa: 31375130
• 3. Liu S, Verma M, et al. "Steroid juriya na iska nau'in 2 innate lymphoid Kwayoyin daga marasa lafiya da tsanani asma: Matsayin thymic stromal lymphopoietin." J Allergy Clin Immunol. 2018 Jan; 141 (1): 257-268.e6. Saukewa: 28433687
• 4. Zheng, Lufeng, et al. "UTR na 3' na pseudogene CYP4Z2P yana haɓaka angiogenesis na ƙari a cikin ciwon nono ta hanyar aiki azaman ceRNA don CYP4Z1." Bincike da maganin ciwon nono (2015): 1-14. Saukewa: 25701119

Bayani

Tofacitinib citrate shine mai hanawa na baki JAK1/2/3 tare da IC50s na 1, 20, da 112 nM, bi da bi. Tofacitinib citrate yana da antibacterial, antifungal da antiviral ayyuka.

Adana

4°C, kariya daga haske

* A cikin ƙarfi: -80 ° C, watanni 6; -20°C, wata 1 (kare haske)

Tsarin sinadaran

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