Ana amfani da Relugolix don magance ciwon daji na prostate a cikin maza.
Alamar Suna: Orgovyx
Class Drug: Antineoplastic - LHRH (GnRH) Masu hana Pituitary mai adawa
Samun: Ana buƙatar takardar sayan magani
Ciki: Tuntuɓi likitan ku. Wannan magani na iya zama cutarwa ga yaron da ba a haifa ba.
Lactation: Tuntuɓi likita kafin amfani

Relugolix wani abu ne na baki, wanda ba peptide gonadotropin mai sakin hormone (GnRH ko luteinizing hormone-releasing hormone (LHRH) antagonist, tare da yuwuwar aikin antineoplastic. Relugolix gasa yana ɗaure kuma yana toshe mai karɓar GnRH a cikin glandar pituitary na baya, wanda duka biyun suna hana GnRH ɗaure ga mai karɓar GnRH kuma yana hana ɓoyewa da sakin duka hormone luteinizing (LH) da kuma hormone mai motsa jiki (FSH). A cikin maza, hanawa na ɓoyewar LH yana hana sakin testosterone daga ƙwayoyin Leydig a cikin gwaje-gwaje. Tun da ana buƙatar testosterone don ci gaba da haɓakar haɓakar prostate, rage matakan testosterone na iya hana yaduwar kwayar cutar ciwon daji na prostate da ke dogara da hormone.

Relugolix shine hormone mai sakin gonadotropin (GnRH) antagonist mai karɓa wanda aka yi amfani da shi wajen maganin yanayi da yawa na amsawar hormone. An fara amincewa da shi a cikin Japan a cikin 2019, a ƙarƙashin sunan alamar Relumina, don maganin alamun fibroids na mahaifa, kuma kwanan nan ta FDA ta Amurka a cikin 2020, ƙarƙashin alamar alama Orgovyx, don maganin ciwon daji na prostate. An kuma yi nazarin Relugolix a cikin alamun bayyanar cututtuka na endometriosis. Relugolix shine farkon (kuma a halin yanzu kawai) mai karɓar GnRH mai karɓa na baki wanda aka amince da shi don maganin cutar sankara ta prostate - irin wannan hanyoyin kwantar da hankali kamar [degarelix] na buƙatar gudanarwar subcutaneous - don haka yana ba da zaɓi na warkewa mara nauyi ga marasa lafiya waɗanda in ba haka ba zasu buƙaci ziyarar asibiti. don gudanarwa ta kwararrun masana kiwon lafiya. Baya ga sauƙin amfani da dangi, an nuna relugolix ya kasance mafi girma a cikin ɓacin rai na matakan testosterone idan aka kwatanta da [leuprolide], wani maganin hanawar androgen da ake amfani da shi wajen maganin ciwon gurguwar prostate.

Relugolix shine Gonadotropin Mai Sakin Hormone Mai karɓar Mai karɓa. Tsarin aikin relugolix shine azaman Gonadotropin Mai Sakin Hormone Recetor Antagonist, da Cytochrome P450 3A Inducer, da Cytochrome P450 2B6 Inducer, da Mai hana Ciwon Ciwon Nono, da P-Glycoprotein Inhibitor. Tasirin ilimin lissafi na relugolix shine ta hanyar Ragewar Sirin GnRH.

Tsarin sinadaran