A matsayin sabon maganin maganin jini na baka, an yi amfani da rivaroxaban sosai a cikin rigakafi da kuma kula da cututtukan thromboembolic venous da rigakafin bugun jini a cikin fibrillation na valvular.Don amfani da rivaroxaban mafi dacewa, yakamata ku san aƙalla waɗannan maki 3.
I. Bambancin da ke tsakanin rivaroxaban da sauran magungunan kashe jini na baka A halin yanzu, magungunan da ake amfani da su na baka sun hada da warfarin, dabigatran, rivaroxaban da sauransu.Daga cikin su, dabigatran da rivaroxaban ana kiransu da sabon maganin maganin jini na baka (NOAC).Warfarin, galibi yana yin tasirin sa na anticoagulant ta hanyar hana haɗakar abubuwan coagulation II (prothrombin), VII, IX da X. Warfarin ba shi da wani tasiri akan abubuwan haɗin gwiwar da aka haɗa don haka yana da saurin farawa na aiki.Dabigatran, galibi ta hanyar hana ayyukan thrombin (prothrombin IIa) kai tsaye, yana yin tasirin anticoagulant.Rivaroxaban, yafi ta hanyar hana ayyukan coagulation factor Xa, don haka rage samar da thrombin (coagulation factor IIa) don aiwatar da anticoagulant sakamako, ba ya shafar ayyukan da aka riga aka samar thrombin, sabili da haka yana da kadan tasiri a kan physiological hemostasis aiki.
2. Alamu na asibiti na rivaroxaban vascular endothelial rauni, jinkirin jini, jini hypercoagulability da sauran dalilai na iya haifar da thrombosis.A wasu marasa lafiya na kasusuwa, tiyatar maye gurbin hip ko gwiwa na samun nasara sosai, amma ba zato ba tsammani su mutu lokacin da suka tashi daga gadon kwanaki kadan bayan tiyatar.Wannan yana yiwuwa saboda majiyyaci ya haifar da thrombosis mai zurfi bayan tiyata kuma ya mutu saboda ciwon huhu wanda ya haifar da thrombus.Rivaroxaban, an yarda da shi don amfani da shi a cikin manya marasa lafiya da ke yin aikin maye gurbin hip ko gwiwa don hana thrombosis (VTE);kuma don maganin thrombosis mai zurfi (DVT) a cikin manya don rage haɗarin sake dawowa DVT da ciwon huhu (PE) bayan DVT mai tsanani.Atrial fibrillation shine arrhythmia na zuciya na yau da kullum tare da yaduwa har zuwa 10% a cikin mutane fiye da shekaru 75.Marasa lafiya tare da fibrillation na atrial suna da dabi'ar jini don tsayawa a cikin atria kuma ya haifar da guda ɗaya, wanda zai iya rushewa kuma ya haifar da bugun jini.Rivaroxaban, an yarda da shi kuma an ba da shawarar ga manya marasa lafiya tare da fibrillation na valvular don rage haɗarin bugun jini da bugun jini.Ingancin rivaroxaban bai yi kasa da na warfarin ba, yawan zubar jini na cikin ciki ya yi kasa da na warfarin, kuma ba a bukatar sa ido akai-akai game da karfin hana daukar ciki, da dai sauransu.
3. Sakamakon anticoagulant na rivaroxaban yana da tsinkaya, tare da taga mai fadi na warkewa, babu tarawa bayan yawancin allurai, da ƙananan hulɗa tare da kwayoyi da abinci, don haka kula da coagulation na yau da kullum ba lallai ba ne.A cikin lokuta na musamman, irin su abin da ake zargi da wuce gona da iri, abubuwan zubar da jini mai tsanani, aikin tiyata na gaggawa, abubuwan da suka faru na thromboembolism ko rashin yarda da rashin yarda, ƙayyade lokacin prothrombin (PT) ko ƙaddara aikin anti-factor Xa ana buƙatar.Tukwici: Rivaroxaban galibi ana daidaita shi ta hanyar CYP3A4, wanda shine tushen furotin P-glycoprotein (P-gp).Don haka, kada a yi amfani da rivaroxaban tare da itraconazole, voriconazole da posaconazole.