Bayani

Hydrochlorothiazide (HCTZ), maganin diuretic mai aiki na baka na rukunin thiazide, yana hana canza TGF-β/Hanyar siginar Smad. Hydrochlorothiazide yana da tasirin shakatawa na jijiyoyi kai tsaye ta hanyar buɗe tashar potassium mai kunna calcium (KCA). Hydrochlorothiazide yana inganta aikin zuciya, yana rage fibrosis kuma yana da tasirin antihypertensive.

Fage

Hydrochlorothiazide magani ne na diuretic na rukunin thiazide.

A cikin Vitro

Hydrochlorothiazide na cikin nau'in thiazide na diuretics. Yana rage ƙarar jini ta hanyar yin aiki akan kodan don rage haɓakawar sodium (Na) a cikin tubule mai rikicewa mai nisa. Babban wurin aiki a cikin nephron yana bayyana akan na'ura mai ɗaukar nauyi Na+-Cl na lantarki ta hanyar yin gasa don rukunin chloride akan mai jigilar kaya. Ta hanyar ɓata jigilar Na a cikin tubule mai murƙushe mai nisa, hydrochlorothiazide yana haifar da natriuresis da asarar ruwa tare. Thiazides yana haɓaka sake dawo da calcium a cikin wannan sashin ta hanyar da ba ta da alaƙa da jigilar sodium. Bugu da ƙari, ta wasu hanyoyin, Hydrochlorothiazide an yi imanin yana rage juriya na jijiyoyin jini.

Hydrochlorothiazide (HCTZ; bygavage na baki; 12.5 mg/kg/d; 8 makonni) ya inganta aikin zuciya, rage yawan fibrosis na zuciya da ƙananan ƙwayar collagen, rage yawan magana na AT1, TGF-β da Smad2 a cikin kyallen jikin zuciya a cikin balagaggun ratsan Sprague Dawley. Bugu da ƙari, hydrochlorothiazide yana rage ƙwayar plasma angiotensin II da aldosterone. Bugu da ƙari, hydrochlorothiazide yana hana angiotensin II-induced TGF-β1 da Smad2 suna magana akan furotin a cikin fibroblasts na bera na jariri.

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