Fage

Calcium Atorvastatin shine mai hana HMG-CoA reductase tare da ƙimar IC50 na 150 nM.
HMG-CoA reductase shine babban enzyme na hanyar mevalonate wanda ke samar da cholesterol. HMG-CoA shine enzyme mai iyakancewa kuma yana da mahimmanci don rage matakan cholesterol na jini. HMG-CoA reductase yana cikin endoplasmic reticulum kuma ya ƙunshi yankuna takwas na transmembrane. Masu hana HMG-CoA reductase na iya haifar da LDL (low density lipoprotein) masu karɓa a cikin hanta. Yana haifar da haɓaka matakan catabolism na plasma LDL da rage yawan ƙwayar cholesterol na plasma wanda shine muhimmin mahimmancin kayyade atherosclerosis. HMG-CoA reductase yana taka muhimmiyar rawa a cikin haɗin cholesterol. HMG-CoA shine manufa ɗaya don rage ƙwayar cholesterol. HMG-CoA reductase shima muhimmin enzyme ne don haɓakawa. Ayyukan HMG-CoA reductase yana da alaƙa da lahani na ƙaura na ƙwayoyin cuta. Hana ayyukansa na iya haifar da zubar jini na intracerebral[1].
Atorvastatin shine mai hana HMG-CoA reductase tare da ƙimar IC50 na 154 nM. Yana da tasiri wajen magance wasu dyslipidemias da hypercholesterolemia[1]. Maganin Atorvastatin a 40 MG yana rage jimlar cholesterol na 40% bayan kwanaki 40. Hakanan ana amfani da ita don kula da masu ciwon bugun jini ko bugun jini tare da matakan cholesterol na al'ada.[2] Atorvastatin kuma yana rage ƙarancin ƙarancin lipoprotein apheresis a cikin marasa lafiya ta hanyar haifar da bayyanar masu karɓar LDL.
An daidaita shi zuwa metabolites da yawa waɗanda ke da mahimmanci don tasirin ayyukan warkewa ta hanyar CYP3A4 (cytochrome P450 3A4).[3]
Magana:
[1]. van Dam M, Zwart M, de Beer F, Smelt AH, Prins MH, Trip MD, Havekes LM, Lansberg PJ, Kastelein JJ: Tsawon inganci da amincin atorvastatin a cikin jiyya na nau'in nau'in III mai tsanani da hadewar dyslipidemia. Zuciya 2002, 88 (3): 234-238.
[2]. Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT et al -matsakaicin adadin cholesterol, a cikin Gwajin Sakamakon Ciwon zuciya na Anglo-Scandinavian-- Rage Hannun Lipid (ASCOT-LLA): gwajin sarrafa bazuwar cibiyoyi da yawa. Lancet 2003, 361 (9364): 1149-1158.
[3]. Lennernas H: Magungunan magunguna na atorvastatin. Clin Pharmacokinet 2003, 42 (13): 1141-1160.

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